Head to Head
| Chile - Cupa | 2021/07/05 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile - Cupa | 2021/07/01 19:30 | La Serena v Colo Colo | L | 1-3 |
| Chile - Primera Division | 2021/06/06 22:00 | Colo Colo v La Serena | L | 2-0 |
| Chile - Primera Division | 2020/12/08 21:30 | Colo Colo v La Serena | W | 0-2 |
| Chile - Primera Division | 2020/03/07 15:00 | La Serena v Colo Colo | L | 1-2 |
| Chile - Cupa | 2017/08/03 00:00 | Colo Colo v La Serena | L | 4-0 |
| Chile - Cupa | 2017/07/09 19:30 | La Serena v Colo Colo | W | 4-1 |
Home History
| Chile - Primera Division | 2021/10/16 23:00 | Melipilla v La Serena | D | 1-1 |
| Chile - Primera Division | 2021/10/10 17:00 | La Serena v Cobresal | W | 2-1 |
| Chile - Primera Division | 2021/10/05 23:30 | Nublense v La Serena | W | 0-1 |
| Chile - Primera Division | 2021/09/28 19:00 | La Serena v Everton de Vina | L | 0-2 |
| Chile - Primera Division | 2021/09/25 18:00 | Union Espanola v La Serena | L | 2-1 |
| Chile - Primera Division | 2021/09/14 17:00 | La Serena v O'Higgins | W | 2-0 |
| Chile - Primera Division | 2021/09/06 23:00 | Universidad de Chile v La Serena | D | 1-1 |
| Chile - Primera Division | 2021/08/31 01:00 | Curico Unido v La Serena | L | 2-0 |
Away History
| Chile - Primera Division | 2021/10/09 23:30 | Colo Colo v Huachipato | W | 2-0 |
| Chile - Primera Division | 2021/10/03 18:30 | Palestino v Colo Colo | W | 1-2 |
| Chile - Primera Division | 2021/09/30 21:30 | Colo Colo v Nublense | L | 0-1 |
| Chile - Primera Division | 2021/09/26 19:30 | Universidad de Chile v Colo Colo | W | 1-3 |
| Chile - Primera Division | 2021/09/14 22:00 | Colo Colo v Everton de Vina | W | 2-0 |
| Chile - Primera Division | 2021/09/08 21:00 | O'Higgins v Colo Colo | W | 2-3 |
| Chile - Cupa | 2021/09/04 20:30 | Colo Colo v Everton de Vina | W | 2-0 |
| Chile - Cupa | 2021/09/01 23:00 | Union Espanola v Colo Colo | W | 2-3 |